ChemIDplus A TOXNET DATABASE

Substance Name: Trichloroethylene [INN:NF]
RN: 79-01-6
InChIKey: XSTXAVWGXDQKEL-UHFFFAOYSA-N

Note

  • A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.

Molecular Formula

  • C2-H-Cl3

Molecular Weight

  • 131.3889
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Fungicide, bactericide, wood preservative
  • Human Data
  • Mutation data
  • Nematocide
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 16
  • 2011 CERCLA Priority List, Rank: 16
  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably anticipated to be a human carcinogen
  • Reportable Quantity (RQ) = 100 lb
  • TWA (50 ppm); STEL (100 ppm); Not suspected as a human carcinogen; BEI
  • TWA 100 mg/m3; Ceiling 200 mg/m3, peak 300 mg/m3 in 5 min in any

Names and Synonyms

Name of Substance

  • Trichloroethylene
  • Trichloroethylene [INN:NF]

MeSH Heading

  • Trichloroethylene

Synonyms

  • 1,1,2-Trichloroethylene
  • 1,1-Dichloro-2-chloroethylene
  • 1,2,2-Trichloroethylene
  • 1-Chloro-2,2-dichloroethylene
  • 4-01-00-00712 (Beilstein Handbook Reference)
  • Acetylene trichloride
  • AI3-00052
  • Algylen
  • Anamenth
  • Benzinol
  • Blacosolv
  • Blancosolv
  • BRN 1736782
  • Caswell No. 876
  • CCRIS 603
  • Cecolene
  • Chlorilen
  • Chlorylea, Chorylen, CirCosolv, Crawhaspol, Dow-Tri, Dukeron, Per-A-Clor, Triad, Trial, TRI-Plus M, Vitran
  • Chlorylen
  • Circosolv
  • Crawhaspol
  • Densinfluat
  • Dow-tri
  • Dukeron
  • EINECS 201-167-4
  • EPA Pesticide Chemical Code 081202
  • Ethene, trichloro-
  • Ethinyl trichloride
  • Ethylene trichloride
  • Ethylene, trichloro-
  • F 1120
  • Fleck-flip
  • Flock FLIP
  • Fluate
  • Germalgene
  • HSDB 133
  • Lanadin
  • Lethurin
  • Narcogen
  • Narkosoid
  • NCI-C04546
  • Nialk
  • NSC 389
  • Perm-A-chlor
  • Petzinol
  • Philex
  • R 1120
  • RCRA waste number U228
  • TCE
  • TCE (chlorohydrocarbon)
  • Threthylen
  • Threthylene
  • Trethylene
  • Tri
  • Tri-clene
  • Tri-plus
  • Tri-plus M
  • Trial
  • Triasol
  • Trichlooretheen
  • Trichlooretheen [Dutch]
  • Trichloorethyleen, tri
  • Trichloorethyleen, tri [Dutch]
  • Trichloraethen
  • Trichloraethen [German]
  • Trichloraethylen, tri
  • Trichloraethylen, tri [German]
  • Trichloraethylenum
  • Trichloran
  • Trichloren
  • Trichlorethylene
  • Trichlorethylene, tri
  • Trichlorethylene, tri [French]
  • Trichlorethylenum
  • Trichloroethene
  • Trichloroethylene
  • Trichloroethylene (IUPAC)
  • Trichloroethylenum
  • Trichloroethylenum [INN-Latin]
  • Tricloretene
  • Tricloretene [Italian]
  • Tricloroetilene
  • Tricloroetilene [DCIT]
  • Tricloroetilene [Italian]
  • Tricloroetileno
  • Tricloroetileno [INN-Spanish]
  • Trielene
  • Trielin
  • Trielina
  • Trielina [Italian]
  • Trieline
  • Triklone N
  • Trilen
  • Trilene
  • Trilene TE-141
  • Trimar
  • UN 1710
  • UNII-290YE8AR51
  • Vestrol
  • Vitran
  • Westrosol

Systematic Names

  • 1,1,2-Trichloroethylene
  • Ethene, 1,1,2-trichloro-
  • Ethene, trichloro-
  • Ethylene, trichloro-
  • Trichloroethylene

Superlist Names

  • Ethene, trichloro-
  • Ethylene, trichloro-
  • RCRA waste no. U228
  • Trichloroethene
  • Trichloroethylene
  • Trichloroethylene [UN1710] [Poison]
  • UN1710

Registry Numbers

CAS Registry Number

  • 79-01-6

Other Registry Number

  • 52037-46-4

System Generated Number

  • 0000079016

Structure Descriptors

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

InChIKey

XSTXAVWGXDQKEL-UHFFFAOYSA-N

Smiles

C(=C\Cl)(/Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 32500mg/m3/2H (32500mg/m3) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
cat LDLo oral 5864mg/kg (5864mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
dog LD50 intraperitoneal 1900mg/kg (1900mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
Link to PubMed
dog LDLo intravenous 150mg/kg (150mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
dog LDLo subcutaneous 150mg/kg (150mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
guinea pig LCLo inhalation 37200ppm/40M (37200ppm)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
human LDLo oral 7gm/kg (7000mg/kg)   Archives of Toxicology. Vol. 35, Pg. 295, 1976.
Link to PubMed
human TCLo inhalation 160ppm/83M (160ppm) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" American Industrial Hygiene Association Journal. Vol. 23, Pg. 167, 1962.
Link to PubMed
human TCLo inhalation 500ppm/16.1Y- (500ppm) KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

KIDNEY, URETER, AND BLADDER: PROTEINURIS
Archives of Toxicology. Vol. 73, Pg. 246, 1999.
Link to PubMed
human TCLo inhalation 812mg/kg (812mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
British Medical Journal. Vol. 2, Pg. 689, 1945.
human TCLo inhalation 6900mg/m3/10M (6900mg/m3) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
man LCLo inhalation 2900ppm (2900ppm)   New Zealand Medical Journal. Vol. 50, Pg. 119, 1951.
Link to PubMed
man TCLo inhalation 110ppm/8H (110ppm) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
British Journal of Industrial Medicine. Vol. 28, Pg. 293, 1971.
Link to PubMed
man TDLo oral 1mL/kg (1mL/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Toxicological Sciences. Vol. 41, Pg. 157, 1998.
man TDLo oral 2143mg/kg (2143mg/kg) GASTROINTESTINAL: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 602, 1969.
mouse LC50 inhalation 8450ppm/4H (8450ppm)   Acta Pharmacologica et Toxicologica. Vol. 9, Pg. 303, 1953.
Link to PubMed
mouse LD50 intravenous 33900ug/kg (33.9mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 141, 1954.
mouse LD50 oral 2402mg/kg (2402mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
National Technical Information Service. Vol. AD-A080-636,
mouse LD50 subcutaneous 16gm/kg (16000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SLEEP
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.
Link to PubMed
rabbit LCLo inhalation 11000ppm (11000ppm)   FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 121, 1970.
rabbit LD50 skin > 20gm/kg (20000mg/kg)   National Technical Information Service. Vol. AD-A062-138,
rabbit LDLo oral 7330mg/kg (7330mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
rabbit LDLo subcutaneous 1800mg/kg (1800mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
rat LCLo inhalation 4800ppm/4H (4800ppm)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 469, 1951.
rat LD50 intraperitoneal 1282mg/kg (1282mg/kg)   Environmental Research. Vol. 40, Pg. 411, 1986.
Link to PubMed
rat LD50 oral 4920mg/kg (4920mg/kg)   Industrial Health. Vol. 32, Pg. 145, 1994.
Link to PubMed
rat LDLo intratracheal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. OTS0520615,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -8.47E+01 deg C   EXP
Boiling Point 87.2 deg C   EXP
log P (octanol-water) 2.42 (none)   EXP
Water Solubility 1280 mg/L 25 EXP
Vapor Pressure 69 mm Hg 25 EXP
Henry's Law Constant 0.00985 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 2.36E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by Syracuse Research Corporation.
See all available property data for this compound, including references.