Substance Name: Lewisite
RN: 541-25-3
InChIKey: GIKLTQKNOXNBNY-OWOJBTEDSA-N

Molecular Formula

  • C2-H2-As-Cl3

Molecular Weight

  • 207.319
2D chemical structure of 541-25-3
 

Classification Codes

Classification Codes

  • Chemical Warfare Agents
  • Human Data
  • Mutation data
  • Noxae
  • Organometallic
  • Poisons
  • Reproductive Effect
  • Skin / Eye Irritant

Superlist Classification Code

  • Threshold Planning Quantity (TPQ) = 10 lb

Links to Resources


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Names and Synonyms

Name of Substance

  • Dichloro(2-chlorovinyl)arsine
  • Lewisite

Synonyms

  • (2-Chloroethenyl)arsonous dichloride
  • 1-Chloro-2-di-chloroarsinoethane
  • 2-Chlorovinyldichloroarsine
  • Arsine, (2-chlorovinyl)dichloro-
  • beta-Chlorovinylbichloroarsine
  • beta-Chlorovinyldichloroarsine
  • CCRIS 4122
  • Chlorovinyl dichloroarsine
  • Chlorovinylarsine dichloride
  • Dichloro(2-chlorovinyl)arsine
  • HSDB 6393
  • Lewisite
  • Lewisite (arsenic compound)
  • Lewisite (L-1)
  • Lewisite 1
  • UN 1556
  • UNII-82TOY8U2KD

Systematic Names

  • Arsine, dichloro(2-chlorovinyl)-
  • Arsonous dichloride, (2-chloroethenyl)-
  • Arsonous dichloride, As-(2-chloroethenyl)-
  • Dichloro(2-chlorovinyl)arsine

Superlist Name

  • Lewisite

Registry Numbers

CAS Registry Number

  • 541-25-3

System Generated Number

  • 0000541253

Structure Descriptors

InChI

1S/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+

InChIKey

GIKLTQKNOXNBNY-OWOJBTEDSA-N

Smiles

C(\[As](Cl)Cl)=C\Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 50gm/m3/30M (50000mg/m3) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Reviews of Environmental Contamination and Toxicology. Vol. 110, Pg. 75, 1989.
Link to PubMed
dog LD50 intravenous 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-508,
dog LD50 skin 15mg/kg (15mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
dog LD50 subcutaneous 2mg/kg (2mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
domestic animals - goat/sheep LD50 skin 10mg/kg (10mg/kg)   National Technical Information Service. Vol. PB158-508,
guinea pig LD50 skin 12mg/kg (12mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
guinea pig LD50 subcutaneous 1mg/kg (1mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
guinea pig LDLo intraperitoneal 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-508,
human LCLo inhalation 6ppm/30M (6ppm)   National Technical Information Service. Vol. PB214-270,
human LDLo skin 37600ug/kg (37.6mg/kg)   EHP, Environmental Health Perspectives. Vol. 98, Pg. 259, 1992.
Link to PubMed
mouse LD50 skin 12mg/kg (12mg/kg)   National Technical Information Service. Vol. PB158-508,
rabbit LD50 intravenous 500ug/kg (.5mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
rabbit LD50 skin 4mg/kg (4mg/kg)   Biochemical Journal. Vol. 41, Pg. 325, 1947.
rabbit LD50 subcutaneous 2mg/kg (2mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.
rat LD50 oral 50mg/kg (50mg/kg)   EHP, Environmental Health Perspectives. Vol. 98, Pg. 259, 1992.
Link to PubMed
rat LD50 skin 15mg/kg (15mg/kg)   National Technical Information Service. Vol. PB158-508,
rat LD50 subcutaneous 1mg/kg (1mg/kg)   Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.20E+00 deg C   EXP
Boiling Point 196.6 deg C   EXP
log P (octanol-water) 2.560 (none)   EST
Water Solubility 500 mg/L   EXP
Vapor Pressure 0.4 mm Hg 25 EXP
Henry's Law Constant 2.18E-04 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.18E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by Syracuse Research Corporation.
See all available property data for this compound, including references.