ChemIDplus A TOXNET DATABASE

Substance Name: Temefos [USAN:INN]
RN: 3383-96-8
InChIKey: WWJZWCUNLNYYAU-UHFFFAOYSA-N

Note

  • An organothiophosphate insecticide.

Molecular Formula

  • C16-H20-O6-P2-S3

Molecular Weight

  • 466.474
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Ectoparasiticide [veterinary]
  • Insecticide
  • Insecticides
  • Pesticides
  • Reproductive Effect
  • Skin / Eye Irritant

Superlist Classification Codes

  • TWA (15 mg/m3 total dust; 5 mg/m3 respirable fraction)
  • TWA 1 mg/m3 (inhalable fraction and vapor); Skin; Not classifiable as a human carcinogen; BEI

Names and Synonyms

Name of Substance

  • Temefos
  • Temefos [USAN:INN]
  • Temephos
  • Temephos [ANSI:BSI:ISO]

MeSH Heading

  • Temefos

Synonyms

  • 27165
  • Abaphos
  • Abate
  • Abate 4-E
  • Abathion
  • AC 52160
  • AI3-27165
  • American cyanamid AC 52,160
  • American cyanamid CL-52160
  • American cyanamid E.I. 52,160
  • Biothion
  • Bis-p-(O,O-dimethyl O-phenylphosphorothioate)sulfide
  • Bithion
  • BRN 1896901
  • Caswell No. 845
  • CCRIS 8942
  • CL 52160
  • Difenphos
  • Difos
  • Diphos
  • Diphos (pesticide)
  • Ecopro 1707
  • EI 52160
  • EINECS 222-191-1
  • ENT 27,165
  • EPA Pesticide Chemical Code 059001
  • Etidronsaeure
  • Experimental insecticide 52160
  • HSDB 956
  • Lypor
  • Nephis
  • Nephis 1G
  • Nimitex
  • Nimitox
  • O,O'-(Thiodi-4,1-phenylene) O,O,O',O'-tetramethyl di(phosphorothioate)
  • O,O'-(Thiodi-4,1-phenylene)bis(O,O-dimethyl phosphorothioate)
  • O,O'-(Thiodi-4,1-phenylene)phosphorothioic acid O,O,O',O'-tetramethyl ester
  • O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl bis(phosphorothioate)
  • O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl di(phosphorothioate)
  • O,O,O',O'-Tetramethyl O,O'-thiodi-P-phenylene bis(phosphorothioate)
  • O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene diphosphorothioate
  • O,O-Dimethyl phosphorothioate O,O-diester with 4,4'-thiodiphenol
  • OMS 786
  • Phenol, 4,4'-thiodi-, O,O-diester with O,O-dimethyl phosphorothioate
  • Phosphorothioic acid, O,O'-(thiodi-p-phenylene) O,O,O',O'-tetramethyl ester (8CI)
  • Procida
  • Swebat
  • Swebate
  • Temefos
  • Temefosum
  • Temefosum [INN-Latin]
  • Temephos
  • Tetrafenphos
  • Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate
  • UNII-ONP3ME32DL

Systematic Names

  • Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
  • Phosphorothioic acid, O,O'-(thiodi-p-phenylene) O,O,O',O'-tetramethyl ester
  • Phosphorothioic acid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol
  • Phosphorothioic acid, Op,Op'-(thiodi-4,1-phenylene) Op,Op,Op',Op'-tetramethyl ester
  • Temephos

Superlist Names

  • Abate
  • Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
  • Temephos

Registry Numbers

CAS Registry Number

  • 3383-96-8

Other Registry Number

  • 53320-58-4

System Generated Number

  • 0003383968

Structure Descriptors

InChI

1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3

InChIKey

WWJZWCUNLNYYAU-UHFFFAOYSA-N

Smiles

P(Oc1ccc(Sc2ccc(OP(OC)(OC)=S)cc2)cc1)(OC)(OC)=S

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 32mg/kg (32mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
Link to PubMed
chicken LD subcutaneous > 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Archives of Environmental Health. Vol. 14, Pg. 283, 1967.
Link to PubMed
duck LD50 oral 79mg/kg (79mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
Link to PubMed
mammal (species unspecified) LD50 oral 4700mg/kg (4700mg/kg)   Journal of the American Veterinary Medical Association. Vol. 152, Pg. 282, 1968.
mammal (species unspecified) LD50 unreported 4gm/kg (4000mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 338, 1971.
mouse LD50 intraperitoneal 683mg/kg (683mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
mouse LD50 oral 223mg/kg (223mg/kg)   Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 1, 1966.
pigeon LD50 oral 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
Link to PubMed
quail LD50 oral 75mg/kg (75mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
Link to PubMed
rabbit LD50 oral 313mg/kg (313mg/kg)   Veterinariya. Veterinary Science. Vol. 60(11), Pg. 63, 1984.
rabbit LD50 skin 970mg/kg (970mg/kg)   Toxicological Information on Cyanamid Insecticides. Vol. 8/1966,
rat LD50 intraperitoneal 912mg/kg (912mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
rat LD50 oral 1gm/kg (1000mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 493, 1973.
rat LD50 skin 1370mg/kg (1370mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 subcutaneous 2302mg/kg (2302mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
rat LD50 unreported 8600mg/kg (8600mg/kg)   Travaux de la Societe de Pharmacie de Montpellier. Vol. 37(1), Pg. 45, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 30 deg C   EXP
log P (octanol-water) 5.96 (none)   EXP
Water Solubility 0.27 mg/L 20 EXP
Vapor Pressure 7.91E-08 mm Hg 25 EST
Henry's Law Constant 1.96E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.36E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by Syracuse Research Corporation.
See all available property data for this compound, including references.