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ChemIDplus A TOXNET DATABASE

Substance Name: Nitric oxide [USAN]
RN: 10102-43-9
InChIKey: ODUCDPQEXGNKDN-UHFFFAOYSA-N

Note

  • A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Molecular Formula

  • N-O

Molecular Weight

  • 31.0139
 

Classification Codes

Classification Codes

  • Anti-Asthmatic Agents
  • Antioxidants
  • Autonomic Agents
  • Bronchodilator agents
  • Cardiovascular Agents
  • Endogenous vasodilator used in the treatment of hypoxic respiratory failure in the term and near-term neonate
  • Endothelium-Dependent Relaxing Factors
  • Free radical scavengers
  • Mutation data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Respiratory System Agents
  • Vasodilator agents

Superlist Classification Codes

  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 100 lb
  • TWA (25 ppm); BEI
  • TWA 25 ppm (30 mg/m3)

Names and Synonyms

Name of Substance

  • Nitric oxide
  • Nitric oxide [USAN]

MeSH Heading

  • Nitric oxide

Synonyms

  • Amidogen, oxo-
  • Bioxyde d'azote
  • Bioxyde d'azote [French]
  • CCRIS 4319
  • EINECS 233-271-0
  • HSDB 1246
  • INOmax
  • Mononitrogen monoxide
  • Nitric oxide
  • Nitrogen monoxide
  • Nitrogen oxide (NO)
  • OHM-11771
  • Oxyde nitrique
  • Oxyde nitrique [French]
  • RCRA waste number P076
  • Stickmonoxyd
  • Stickmonoxyd [German]
  • UN 1660
  • UNII-31C4KY9ESH

Systematic Names

  • Nitric oxide
  • Nitrogen monoxide
  • Nitrogen oxide (NO)

Superlist Names

  • Nitric oxide
  • Nitric oxide 10% by volume or more
  • Nitric oxide, compressed
  • Nitric oxide, compressed [UN1660] [Poison gas]
  • Nitrogen oxide
  • Nitrogen oxide (NO)
  • RCRA waste no. P076
  • UN1660

Registry Numbers

CAS Registry Number

  • 10102-43-9

Other Registry Numbers

  • 51005-20-0
  • 51005-21-1
  • 53851-19-7
  • 90452-29-2
  • 90880-94-7

System Generated Number

  • 0010102439

Structure Descriptors

InChI

1S/HNO/c1-2/h1H

InChIKey

ODUCDPQEXGNKDN-UHFFFAOYSA-N

Smiles

N=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 5000ppm/25M (5000ppm) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
British Journal of Anesthesia. Vol. 39, Pg. 393, 1967.
Link to PubMed
mouse LCLo inhalation 320ppm (320ppm) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 181, Pg. 145, 1936.
rat LC50 inhalation 1068mg/m3/4H (1068mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(4), Pg. 52, 1975.