ChemIDplus A TOXNET DATABASE

Name: Valium
Substance Name: Diazepam [USAN:USP:INN:BAN:JAN]
RN: 439-14-5
InChIKey: AAOVKJBEBIDNHE-UHFFFAOYSA-N

Note

  • A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

Molecular Formula

  • C16-H13-Cl-N2-O

Molecular Weight

  • 284.7447
 

Classification Codes

Classification Codes

  • Adjuvants, anesthesia
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, intravenous
  • Anti-anxiety agents
  • Anticonvulsants
  • Antiemetics
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA modulators
  • Gastrointestinal Agents
  • Human Data
  • Hypnotics and Sedatives
  • Muscle relaxants, central
  • Mutation data
  • Neuromuscular Agents
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Sedative-hypnotic
  • Tranquilizing Agents
  • Tumor data

Superlist Classification Codes

  • DEA Schedule IV
  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Diazepam
  • Diazepam [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Diazepam

Synonyms

  • 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
  • 5-24-04-00300 (Beilstein Handbook Reference)
  • 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine
  • 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
  • Alboral
  • Aliseum
  • Amiprol
  • An-Ding
  • Ansilive
  • Ansiolin
  • Ansiolisina
  • Antenex
  • Anxicalm
  • Anxionil
  • Apaurin
  • Apo-diazepam
  • Apozepam
  • Armonil
  • Arzepam
  • Assival
  • Atensine
  • Atilen
  • Azedipamin
  • Baogin
  • Bensedin
  • Benzopin
  • Best [Pharaceutical]
  • Betapam
  • Bialzepam
  • Britazepam
  • BRN 0754371
  • Calmaven
  • Calmocitene
  • Calmociteno
  • Calmod
  • Calmpose
  • Caudel
  • CB 4261
  • CCRIS 6009
  • Centrazepam
  • Cercine
  • Ceregulart
  • Chuansuan
  • Condition
  • D-Pam
  • Desconet
  • Desloneg
  • Diacepan
  • Diaceplex
  • Dialag
  • Dialar
  • Diapam
  • Diapax
  • Diapine
  • Diaquel
  • Diastat
  • Diastat Acudial
  • Diatran
  • Diazem
  • Diazemuls
  • Diazepam
  • Diazepam Dak
  • Diazepam Desitin
  • Diazepam Elmu
  • Diazepam Fabra
  • Diazepam intensol
  • Diazepam Nordic
  • Diazepam Rectubes
  • Diazepam Stada
  • Diazepam-Eurogenerics
  • Diazepam-Lipuro
  • Diazepam-ratiopharm
  • Diazepamu
  • Diazepamu [Polish]
  • Diazepamum
  • Diazepamum [INN-Latin]
  • Diazepan
  • Diazepan leo
  • Diazepin
  • Diazetard
  • Dienpax
  • Dipaz
  • Dipezona
  • Disopam
  • Dizac
  • Domalium
  • Doval
  • Drenian
  • Ducene
  • Duksen
  • Dupin
  • Duxen
  • DZP
  • e-Pam
  • EINECS 207-122-5
  • Elcion CR
  • Eridan
  • Euphorin P
  • Eurosan
  • Evacalm
  • Faustal
  • Faustan
  • Freudal
  • Frustan
  • Gewacalm
  • Gihitan
  • Gradual
  • Gubex
  • Horizon
  • HSDB 3057
  • Iazepam
  • Jinpanfan
  • Kabivitrum
  • Kiatrium
  • Kratium
  • Kratium 2
  • LA III
  • LA-111
  • Lamra
  • Lembrol
  • Levium
  • Liberetas
  • Lizan
  • Lovium
  • Mandro
  • Mandro-Zep
  • Medipam
  • Mentalium
  • Metamidol
  • Methyl diazepinone
  • Methyldiazepinone
  • Methyldiazepinone (pharmaceutical)
  • Metil Gobanal
  • Morosan
  • Nellium
  • Nerozen
  • Nervium
  • Neurolytril
  • Nivalen
  • Nixtensyn
  • Noan
  • Notense
  • Novazam
  • Novodipam
  • NSC 169897
  • NSC-77518
  • Ortopsique
  • Paceum
  • Paralium
  • Paranten
  • Parzam
  • Pax
  • Paxate
  • Paxel
  • Paxum
  • Placidox 10
  • Placidox 2
  • Placidox 5
  • Plidan
  • Plumiaz
  • Pomin
  • Propam
  • Prozepam
  • Psychopax
  • Q-Pam
  • Quetinil
  • Quiatril
  • Quievita
  • Radizepam
  • Relaminal
  • Relanium
  • Relax
  • Reliver
  • Renborin
  • Ro 5-2807
  • Ruhsitus
  • Saromet
  • Sedipam
  • Seduksen
  • Seduxen
  • Serenack
  • Serenamin
  • Serenzin
  • Setonil
  • Sibazon
  • Sico Relax
  • Simasedan
  • Sipam
  • Solis
  • Sonacon
  • Stesolid
  • Stesolin
  • Tensopam
  • Tranimul
  • Trankinon
  • Tranqdyn
  • Tranquirit
  • Trazepam
  • Umbrium
  • UNII-Q3JTX2Q7TU
  • Unisedil
  • Usempax AP
  • Valaxona
  • Valeo
  • Valiquid
  • Valitran
  • Valium
  • Valrelease
  • Valuzepam
  • Vanconin
  • Vatran
  • Vazen
  • Velium
  • Vival
  • Vivol
  • Winii
  • WY-3467
  • Zepaxid
  • Zipan

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
  • Diazepam

Superlist Names

  • DEA No. 2765
  • Diazepam

Registry Numbers

CAS Registry Number

  • 439-14-5

Other Registry Numbers

  • 11100-37-1
  • 53320-84-6

System Generated Number

  • 0000439145

Structure Descriptors

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChIKey

AAOVKJBEBIDNHE-UHFFFAOYSA-N

Smiles

C1(=NCC(=O)N(c2c1cc(cc2)Cl)C)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 parenteral > 800mg/kg (800mg/kg)   Drugs in Japan Vol. -, Pg. 500, 1995.
infant TDLo intravenous 150ug/kg (.15mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 2, Pg. 298, 1977.
Link to PubMed
mammal (species unspecified) LD50 oral 500mg/kg (500mg/kg)   Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 320, Pg. 242, 1991.
Link to PubMed
mammal (species unspecified) LD50 unreported 110mg/kg (110mg/kg)   Pharmaceutical Chemistry Journal Vol. 25, Pg. 193, 1991.
man TDLo intravenous 71ug/kg/1M-C (.071mg/kg) VASCULAR: OTHER CHANGES Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 125, 1983.
Link to PubMed
man TDLo intravenous 143ug/kg (.143mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1052, 1977.
Link to PubMed
man TDLo oral 143ug/kg (.143mg/kg) SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE
British Journal of Clinical Pharmacology. Vol. 1, Pg. 335, 1974.
mouse LD50 intramuscular 65mg/kg (65mg/kg)   European Journal of Pharmacology. Vol. 13, Pg. 150, 1971.
Link to PubMed
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
Link to PubMed
mouse LD50 intravenous 25mg/kg (25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.
Link to PubMed
mouse LD50 oral 48mg/kg (48mg/kg)   Pharmaceutical Chemistry Journal Vol. 17, Pg. 30, 1983.
mouse LD50 parenteral 80mg/kg (80mg/kg)   United States Patent Document. Vol. #4371536,
mouse LD50 rectal 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2226, 1992.
mouse LD50 skin 800mg/kg (800mg/kg)   Anesteziologiya i Reanimatologiya. Vol. (4), Pg. 57, 1980.
Link to PubMed
mouse LD50 subcutaneous 800mg/kg (800mg/kg)   United States Patent Document. Vol. #3966793,
mouse LD50 unreported 140mg/kg (140mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Pharmaceutical Chemistry Journal Vol. 18, Pg. 266, 1984.
rabbit LD50 intravenous 9mg/kg (9mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
Link to PubMed
rabbit LD50 oral 328mg/kg (328mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965.
Link to PubMed
rat LD50 intraperitoneal 46500ug/kg (46.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat LD50 intravenous 32mg/kg (32mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965.
Link to PubMed
rat LD50 oral 249mg/kg (249mg/kg)   Drugs in Japan Vol. -, Pg. 500, 1995.
rat LD50 parenteral 131mg/kg (131mg/kg)   Drugs in Japan Vol. -, Pg. 500, 1995.
rat LD50 rectal 600mg/kg (600mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2226, 1992.
rat LD50 subcutaneous 6350ug/kg (6.35mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
women TDLo intramuscular 181ug/kg (.181mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: CHANGE IN RATE
British Medical Journal. Vol. 1, Pg. 144, 1977.
women TDLo oral 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) British Journal of Obstetrics and Gynaecology. Vol. 100, Pg. 185, 1993.
Link to PubMed

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 132 deg C   EXP
pKa Dissociation Constant 3.4 (none)   EXP
log P (octanol-water) 2.82 (none)   EXP
Water Solubility 50 mg/L 25 EXP
Vapor Pressure 2.78E-08 mm Hg 25 EST
Henry's Law Constant 3.64E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.90E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by Syracuse Research Corporation.
See all available property data for this compound, including references.